View source for 4b87


==Crystal structure of human DNA cross-link repair 1A==
<StructureSection load='4b87' size='340' side='right' caption='[[4b87]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4b87]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B87 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B87 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b87 OCA], [http://pdbe.org/4b87 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b87 RCSB], [http://www.ebi.ac.uk/pdbsum/4b87 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b87 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN]] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Allerston, C K]]
[[Category: Arrowsmith, C H]]
[[Category: Berridge, G]]
[[Category: Bountra, C]]
[[Category: Carpenter, E P]]
[[Category: Delft, F Von]]
[[Category: Edwards, A]]
[[Category: Gileadi, O]]
[[Category: Kochan, G]]
[[Category: Krojer, T]]
[[Category: Mahajan, P]]
[[Category: Vollmar, M]]
[[Category: Yue, W W]]
[[Category: Cancer]]
[[Category: Chemotherapy]]
[[Category: Dclre]]
[[Category: Dclre1a]]
[[Category: Hydrolase]]
[[Category: Interstrand crosslink repair]]
[[Category: Nitrogen mustard]]
[[Category: Pso2 homolog]]