View source for 5eho


==Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach==
<StructureSection load='5eho' size='340' side='right' caption='[[5eho]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5eho]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EHO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5O1:~{N}8-CYCLOHEXYL-~{N}2-[2-METHOXY-4-(1-METHYLPYRAZOL-4-YL)PHENYL]PYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5O1</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eh0|5eh0]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eho OCA], [http://pdbe.org/5eho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eho RCSB], [http://www.ebi.ac.uk/pdbsum/5eho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eho ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Baker, R]]
[[Category: Blagg, J]]
[[Category: Box, G]]
[[Category: Brandon, A De Haven]]
[[Category: Burke, R]]
[[Category: Cronin, N]]
[[Category: Eccles, S A]]
[[Category: Faisal, A]]
[[Category: Fee, L O]]
[[Category: Hayes, A]]
[[Category: Henley, A T]]
[[Category: Hoelder, S]]
[[Category: Innocenti, P]]
[[Category: Linardopoulos, S]]
[[Category: Mak, G]]
[[Category: Montfort, R L.M van]]
[[Category: Naud, N]]
[[Category: Raymaud, F I]]
[[Category: Roberts, J]]
[[Category: Saville, J]]
[[Category: Schmitt, J]]
[[Category: Solanki, S]]
[[Category: Valenti, M]]
[[Category: Westwood, I M]]
[[Category: Woodward, H L]]
[[Category: Transferase]]