View source for 1pz8

[[Image:1pz8.jpg|left|200px]]

 {{Structure
|PDB= 1pz8 |SIZE=350|CAPTION= <scene name='initialview01'>1pz8</scene>, resolution 2.35&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
|ACTIVITY= 
|GENE= AGRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
|DOMAIN=
|RELATEDENTRY=[[1pz7|1PZ7]], [[1q56|1Q56]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pz8 OCA], [http://www.ebi.ac.uk/pdbsum/1pz8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pz8 RCSB]</span>
}}

'''Modulation of agrin function by alternative splicing and Ca2+ binding'''


==Overview==
The aggregation of acetylcholine receptors on postsynaptic membranes is a key step in neuromuscular junction development. This process depends on alternatively spliced forms of the proteoglycan agrin with "B-inserts" of 8, 11, or 19 residues in the protein's globular C-terminal domain, G3. Structures of the neural B8 and B11 forms of agrin-G3 were determined by X-ray crystallography. The structure of G3-B0, which lacks inserts, was determined by NMR. The agrin-G3 domain adopts a beta jellyroll fold. The B insert site is flanked by four loops on one edge of the beta sandwich. The loops form a surface that corresponds to a versatile interaction interface in the family of structurally related LNS proteins. NMR and X-ray data indicate that this interaction interface is flexible in agrin-G3 and that flexibility is reduced by Ca(2+) binding. The plasticity of the interaction interface could enable different splice forms of agrin to select between multiple binding partners.

==About this Structure==
1PZ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZ8 OCA]. 

==Reference==
Modulation of agrin function by alternative splicing and Ca2+ binding., Stetefeld J, Alexandrescu AT, Maciejewski MW, Jenny M, Rathgeb-Szabo K, Schulthess T, Landwehr R, Frank S, Ruegg MA, Kammerer RA, Structure. 2004 Mar;12(3):503-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15016366 15016366]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Alexandrescu, A T.]]
[[Category: Frank, S.]]
[[Category: Jenny, M.]]
[[Category: Kammerer, R A.]]
[[Category: Landwehr, R.]]
[[Category: Maciejewski, M W.]]
[[Category: Rathgeb-Szabo, K.]]
[[Category: Ruegg, M A.]]
[[Category: Schulthess, T.]]
[[Category: Stetefeld, J.]]
[[Category: agrin]]

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