View source for 1oxb

[[Image:1oxb.jpg|left|200px]]

 {{Structure
|PDB= 1oxb |SIZE=350|CAPTION= <scene name='initialview01'>1oxb</scene>, resolution 2.30&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY= 
|GENE= YPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SLN1 OR YPD2 OR YIL147C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
|DOMAIN=
|RELATEDENTRY=[[1qsp|1QSP]], [[1oxk|1OXK]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oxb OCA], [http://www.ebi.ac.uk/pdbsum/1oxb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oxb RCSB]</span>
}}

'''Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)'''


==Overview==
In Saccharomyces cerevisiae, a branched multistep phosphorelay signaling pathway regulates cellular adaptation to hyperosmotic stress. YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7). These four proteins are evolutionarily related to the well-characterized "two-component" regulatory proteins from bacteria. Although structural information is available for many two-component signaling proteins, there are very few examples of complexes between interacting phosphorelay partners. Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.

==About this Structure==
1OXB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OXB OCA]. 

==Reference==
The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems., Xu Q, Porter SW, West AH, Structure. 2003 Dec;11(12):1569-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14656441 14656441]
[[Category: Protein complex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Porter, S W.]]
[[Category: West, A H.]]
[[Category: Xu, Q.]]
[[Category: histidine-containing phosphotransfer protein]]
[[Category: hpt domain]]
[[Category: phosphorelay protein]]
[[Category: response regulator]]
[[Category: sln1p]]
[[Category: two-component signaling protein]]
[[Category: ypd1p]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:43 2008''