View source for 5lsa


==human catechol O-methyltransferase in complex with SAM and DNC at 1.50A==
<StructureSection load='5lsa' size='340' side='right' caption='[[5lsa]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lsa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LSA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DNC:3,5-DINITROCATECHOL'>DNC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsa OCA], [http://pdbe.org/5lsa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lsa RCSB], [http://www.ebi.ac.uk/pdbsum/5lsa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsa ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/COMT_HUMAN COMT_HUMAN]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. 
__TOC__
</StructureSection>
[[Category: Catechol O-methyltransferase]]
[[Category: Ehler, A]]
[[Category: Lerner, C]]
[[Category: Rudolph, M G]]
[[Category: Methyltransferase]]
[[Category: Neurotransmitter degradation]]
[[Category: Transferase]]