View source for Stimulator of interferon genes

<StructureSection load='4loh' size='350' side='right' caption='Structure of human STING CTD complex with c-GMP-AMP (stick model) (PDB entry [[4loh]])' scene=''>
    
'''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites.  STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses.  The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP.  STING is a facilitator of innate immune signaling<ref>PMID:26980676</ref>.

== Structural highlights ==
The cyclic dinucleotide binds the STING in a U-shaped cleft between the 2 monomers<ref>PMID:23910378</ref>.
</StructureSection>

==3D structures of STING==
(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*Stimulator of interferon genes

**[[4ef5]], [[4f5w]], [[4f9e]] – hSTING CTD - human<br />
**[[4f5e]] – hSTING CTD (mutant)   <br />
**[[4jc5]], [[4kc0]] – mSTING CTD - mouse  <br />

*Stimulator of interferon genes complex with ligand

**[[4ef4]], [[4f5y]], [[4f9g]] – hSTING CTD + c-di-GMP <br />
**[[4emt]] – hSTING residues 155-341 + c-di-GMP  <br />
**[[4f5d]] – hSTING CTD (mutant) + c-di-GMP  <br />
**[[4kby]] – mSTING CTD + c-di-GMP  <br />
**[[4ksy]] – hSTING CTD + cGAMP <br />
**[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br />
**[[4loj]], [[4lok]] – mSTING CTD + c-di-GMP derivative<br />
**[[4lol]] – mSTING CTD + chemptherapeutic agent DMXAA<br />
**[[4qxo]], [[4qxp]], [[4qxq]], [[4qxr]] – hSTING CTD + chemptherapeutic agent DMXAA<br />
}}
== References ==
<references/>
[[Category:Topic Page]]