View source for 3alz


==Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I)==
<StructureSection load='3alz' size='340' side='right' caption='[[3alz]], [[Resolution|resolution]] 4.51&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3alz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotton-top_tamarin Cotton-top tamarin] and [http://en.wikipedia.org/wiki/Measf Measf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ALZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3alw|3alw]], [[3alx|3alx]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hemagglutinin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70146 MEASF]), SLAM (CD150) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9490 Cotton-top tamarin])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3alz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alz OCA], [http://pdbe.org/3alz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3alz RCSB], [http://www.ebi.ac.uk/pdbsum/3alz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3alz ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor. Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM. The MV-H head domain binds to a beta-sheet of the membrane-distal ectodomain of SLAM using the side of its beta-propeller fold. This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their beta-propeller. The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations. Notably, the crystal structures obtained show two forms of the MV-H-SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering.

Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM.,Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y Nat Struct Mol Biol. 2011 Feb;18(2):135-41. Epub 2011 Jan 9. PMID:21217702<ref>PMID:21217702</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3alz" style="background-color:#fffaf0;"></div>

==See Also==
*[[Hemagglutinin|Hemagglutinin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cotton-top tamarin]]
[[Category: Measf]]
[[Category: Hashiguchi, T]]
[[Category: Kamishikiryo, J]]
[[Category: Kubota, M]]
[[Category: Maenaka, K]]
[[Category: Maita, N]]
[[Category: Ose, T]]
[[Category: Yanagi, Y]]
[[Category: Beta-sandwich]]
[[Category: Immunoglobulin fold]]
[[Category: Six-bladed beta-propeller fold]]
[[Category: Viral protein-membrane protein complex]]
[[Category: Viral protein-receptor complex]]