View source for 4cxw


==Crystal structure of human FTO in complex with subfamily-selective inhibitor 12==
<StructureSection load='4cxw' size='340' side='right' caption='[[4cxw]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4cxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MK:(2E)-4-[N-(4-BENZYL-PYRIDINE-3-CARBONYL)-HYDRAZINO]-4-OXO-BUT-2-ENOIC+ACID'>6MK</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cxx|4cxx]], [[4cxy|4cxy]], [[4cxz|4cxz]], [[4cy0|4cy0]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxw OCA], [http://pdbe.org/4cxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cxw RCSB], [http://www.ebi.ac.uk/pdbsum/4cxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxw ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:[http://omim.org/entry/612938 612938]]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years.<ref>PMID:19559399</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/FTO_HUMAN FTO_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.<ref>PMID:18775698</ref> <ref>PMID:20376003</ref>  

==See Also==
*[[Dioxygenase|Dioxygenase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chen, Y]]
[[Category: Gao, Y G]]
[[Category: Hong, W]]
[[Category: Lau, L Z.M]]
[[Category: Sun, L]]
[[Category: Tan, J]]
[[Category: Toh, D W]]
[[Category: Woon, E C.Y]]
[[Category: Oxidoreductase]]
[[Category: Small molecular probe]]