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==Regulatory domain structure of NMB2055 (MetR), C103S C106S mutant, a LysR family regulator from N. meningitidis==
<StructureSection load='4ab6' size='340' side='right' caption='[[4ab6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ab6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AB6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ab5|4ab5]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ab6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ab6 OCA], [http://pdbe.org/4ab6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ab6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ab6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ab6 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The crystal structure of the regulatory domain of NMB2055, a putative MetR regulator from Neisseria meningitidis, is reported at 2.5 A resolution. The structure revealed that there is a disulfide bond inside the predicted effector-binding pocket of the regulatory domain. Mutation of the cysteines (Cys103 and Cys106) that form the disulfide bond to serines resulted in significant changes to the structure of the effector pocket. Taken together with the high degree of conservation of these cysteine residues within MetR-related transcription factors, it is suggested that the Cys103 and Cys106 residues play an important role in the function of MetR regulators.

Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis.,Sainsbury S, Ren J, Saunders NJ, Stuart DI, Owens RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):730-7. Epub, 2012 Jun 22. PMID:22750853<ref>PMID:22750853</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 4ab6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Neimi]]
[[Category: Owens, R J]]
[[Category: Ren, J]]
[[Category: Sainsbury, S]]
[[Category: Saunders, N J]]
[[Category: Stuart, D I]]
[[Category: Transcription]]
[[Category: Transcription factor]]