View source for 2xdg


==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.==
<StructureSection load='2xdg' size='340' side='right' caption='[[2xdg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XDG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdg OCA], [http://pdbe.org/2xdg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xdg RCSB], [http://www.ebi.ac.uk/pdbsum/2xdg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdg ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN]] Isolated growth hormone deficiency type IB. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11232012</ref> <ref>PMID:10084571</ref> <ref>PMID:12534354</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN]] Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xdg ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Hormone|Hormone]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Arrowsmith, C H]]
[[Category: Barr, A J]]
[[Category: Bountra, C]]
[[Category: Brown, N Burgess]]
[[Category: Carpenter, E P]]
[[Category: Chaikuad, A]]
[[Category: Delft, F Von]]
[[Category: Edwards, A]]
[[Category: Muniz, J R.C]]
[[Category: Pike, A C.W]]
[[Category: Quigley, A]]
[[Category: Shrestha, L]]
[[Category: Vollmar, M]]
[[Category: Weigelt, J]]
[[Category: Yang, J]]
[[Category: Membrane protein]]
[[Category: Receptor]]
[[Category: Signaling protein]]