View source for 3pp2


==Crystal structure of the pleckstrin homology domain of ArhGAP27==
<StructureSection load='3pp2' size='340' side='right' caption='[[3pp2]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3pp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PP2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP27, CAMGAP1, SH3D20, PP905 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pp2 OCA], [http://pdbe.org/3pp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pp2 RCSB], [http://www.ebi.ac.uk/pdbsum/3pp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pp2 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RHG27_HUMAN RHG27_HUMAN]] Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). 
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</StructureSection>
[[Category: Human]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Edwards, A M]]
[[Category: Li, Y]]
[[Category: Nedyalkova, L]]
[[Category: Park, H]]
[[Category: Structural genomic]]
[[Category: Shen, L]]
[[Category: Tempel, W]]
[[Category: Tong, Y]]
[[Category: Weigelt, J]]
[[Category: Wernimont, A K]]
[[Category: Gtpase activator]]
[[Category: Hydrolase activator]]
[[Category: Ph domain]]
[[Category: Pleckstrin homology domain]]
[[Category: Sgc]]