View source for 1bn5

[[Image:1bn5.gif|left|200px]]<br />
<applet load="1bn5" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1bn5, resolution 1.8&Aring;" />
'''HUMAN METHIONINE AMINOPEPTIDASE 2'''<br />

==Overview==
The fungal metabolite fumagillin suppresses the formation of new blood, vessels, and a fumagillin analog is currently in clinical trials as an, anticancer agent. The molecular target of fumagillin is methionine, aminopeptidase-2 (MetAP-2). A 1.8 A resolution crystal structure of free, and inhibited human MetAP-2 shows a covalent bond formed between a, reactive epoxide of fumagillin and histidine-231 in the active site of, MetAP-2. Extensive hydrophobic and water-mediated polar interactions with, other parts of fumagillin provide additional affinity. Fumagillin-based, drugs inhibit MetAP-2 but not MetAP-1, and the three-dimensional structure, also indicates the likely determinants of this specificity. The structural, basis for fumagillin's potency and specificity forms the starting point, for structure-based drug design.

==About this Structure==
1BN5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO and TBU as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Structure known Active Site: CO2. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BN5 OCA]. 

==Reference==
Structure of human methionine aminopeptidase-2 complexed with fumagillin., Liu S, Widom J, Kemp CW, Crews CM, Clardy J, Science. 1998 Nov 13;282(5392):1324-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9812898 9812898]
[[Category: Homo sapiens]]
[[Category: Methionyl aminopeptidase]]
[[Category: Single protein]]
[[Category: Clardy, J.C.]]
[[Category: Crews, C.M.]]
[[Category: Kemp, C.W.]]
[[Category: Liu, S.]]
[[Category: Widom, J.]]
[[Category: CO]]
[[Category: TBU]]
[[Category: hydrolase]]
[[Category: methionine aminopeptidase]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 15:55:52 2007''