View source for 3rnv


==Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase==
<StructureSection load='3rnv' size='340' side='right' caption='[[3rnv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tumvj Tumvj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNV FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HC-Pro ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12230 TUMVJ])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Helper-component_proteinase Helper-component proteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.45 3.4.22.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnv OCA], [http://pdbe.org/3rnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rnv RCSB], [http://www.ebi.ac.uk/pdbsum/3rnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnv ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/POLG_TUMVJ POLG_TUMVJ]] Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.  Nuclear inclusion protein B: a RNA-dependent RNA polymerase that plays an essential role in the virus replication.  Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).  Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication (By similarity).  Both 6K peptides are indispensable for virus replication (By similarity).  Nuclear inclusion protein A: has RNA-binding and proteolytic activities. 
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</StructureSection>
[[Category: Helper-component proteinase]]
[[Category: Tumvj]]
[[Category: Ye, K]]
[[Category: Cysteine protease]]
[[Category: Hydrolase]]
[[Category: Proteolysis]]