View source for 4nkf


==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates==
<StructureSection load='4nkf' size='340' side='right' caption='[[4nkf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NKF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n9u|4n9u]], [[4ng6|4ng6]], [[1yq7|1yq7]], [[1zw5|1zw5]], [[4nke|4nke]], [[4nua|4nua]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nkf OCA], [http://pdbe.org/4nkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nkf RCSB], [http://www.ebi.ac.uk/pdbsum/4nkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nkf ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. 

==See Also==
*[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]]
__TOC__
</StructureSection>
[[Category: Barnett, B L]]
[[Category: Delft, F Von]]
[[Category: Dunford, J E]]
[[Category: Ebetino, F H]]
[[Category: Muniz, J R.C]]
[[Category: Oppermann, U]]
[[Category: Russell, R G.G]]
[[Category: Tsoumpra, M K]]
[[Category: Walter, R L]]
[[Category: Alpha-helical prenyltransferase]]
[[Category: Bisphosphonate]]
[[Category: Cholesterol synthesis]]
[[Category: Isoprene biosynthesis]]
[[Category: Isoprenoid pathway]]
[[Category: Lipid synthesis]]
[[Category: Steroid biosynthesis]]
[[Category: Transferase]]