View source for 3vtq


==Novel HIV fusion inhibitor==
<StructureSection load='3vtq' size='340' side='right' caption='[[3vtq]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vtq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VTQ FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vie|3vie]], [[3vgx|3vgx]], [[3vtp|3vtp]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vtq OCA], [http://pdbe.org/3vtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vtq RCSB], [http://www.ebi.ac.uk/pdbsum/3vtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vtq ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q9YP39_9HIV1 Q9YP39_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447]  The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity). 
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</StructureSection>
[[Category: Cui, S]]
[[Category: Waltersperger, S]]
[[Category: Wang, M]]
[[Category: Yao, X]]
[[Category: 6-helix bundle]]
[[Category: Coiled-coil]]
[[Category: Fusion inhibitor]]
[[Category: M-t hook]]
[[Category: Membrane]]
[[Category: Viral protein-antiviral protein complex]]