View source for 4hsv


==Crystal Structure of CXCL4L1==
<StructureSection load='4hsv' size='340' side='right' caption='[[4hsv]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4hsv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSV FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f9q|1f9q]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF4V1, CXCL4V1, SCYB4V1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsv OCA], [http://pdbe.org/4hsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hsv RCSB], [http://www.ebi.ac.uk/pdbsum/4hsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsv ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PF4V_HUMAN PF4V_HUMAN]] Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Chemokines, a sub-family of cytokines, are small, secreted proteins that mediate a variety of biological processes. Various chemokines adopt remarkable conserved tertiary structure comprising an anti-parallel beta-sheet core domain followed by a C-terminal helix that packs onto the beta-sheet. The conserved structural feature has been considered critical for chemokine function, including binding to cell surface receptor. The recently isolated variant, CXCL4L1, is a homologue of CXCL4 chemokine (or platelet factor 4, PF4) with potent anti-angiogenic activity and differed only in three amino acid residues of P58L, K66E and L67H. In this study, we show by X-ray structural determination that CXCL4L1 adopts a previously unrecognized structure at its C-terminus. The orientation of the C-terminal helix protrudes into the aqueous space to expose the entire helix. The alternative helix orientation modifies the overall chemokine shape and surface properties. The L67H mutation is mainly responsible for the swing-out effect of the helix, while mutations of P58L and K66E only act secondarily. This is the first observation that reports an open conformation of the C-terminal helix in a chemokine. This change leads to a decrease of its glycosaminoglycan-binding properties and to an enhancement of its anti-angiogenic and anti-tumor effects. This unique structure is recent in evolution and has allowed CXCL4L1 to gain novel functional properties.

Alternative C-Terminal Helix Orientation Alters Chemokine Function: Structure of the Anti-angiogenic Chemokine, CXCL4L1.,Kuo JH, Chen YP, Liu JS, Dubrac A, Quemener C, Prats H, Bikfalvi A, Wu WG, Sue SC J Biol Chem. 2013 Mar 27. PMID:23536183<ref>PMID:23536183</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4hsv" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Kuo, J H]]
[[Category: Liu, J S]]
[[Category: Sue, S C]]
[[Category: Wu, W G]]
[[Category: Anti-angiogenesis]]
[[Category: Antitumor protein]]
[[Category: Extracellular]]
[[Category: Heparin]]