View source for 4er3


==Crystal Structure of Human DOT1L in complex with inhibitor EPZ004777==
<StructureSection load='4er3' size='340' side='right' caption='[[4er3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4er3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eqz|4eqz]], [[4er0|4er0]], [[4er5|4er5]], [[4er6|4er6]], [[4er7|4er7]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er3 OCA], [http://pdbe.org/4er3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4er3 RCSB], [http://www.ebi.ac.uk/pdbsum/4er3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4er3 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. 

==See Also==
*[[Histone methyltransferase|Histone methyltransferase]]
__TOC__
</StructureSection>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Human]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bradner, J E]]
[[Category: Brown, P J]]
[[Category: Edwards, A M]]
[[Category: Federation, A]]
[[Category: Li, Y]]
[[Category: Marineau, J]]
[[Category: Nguyen, K T]]
[[Category: Qi, J]]
[[Category: Structural genomic]]
[[Category: Schapira, M]]
[[Category: Scopton, A]]
[[Category: Tempel, W]]
[[Category: Vedadi, M]]
[[Category: Wernimont, A K]]
[[Category: Yu, W]]
[[Category: Epigenetic]]
[[Category: Histone]]
[[Category: Methyltransferase]]
[[Category: Transferase-transferase inhibitor complex]]