View source for 3ewv


==Crystal Structure of calmodulin complexed with a peptide==
<StructureSection load='3ewv' size='340' side='right' caption='[[3ewv]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ewv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EWV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ewt|3ewt]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ewv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewv OCA], [http://pdbe.org/3ewv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ewv RCSB], [http://www.ebi.ac.uk/pdbsum/3ewv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewv ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TNR16_HUMAN TNR16_HUMAN]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.<ref>PMID:14966521</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ewv ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Calmodulin|Calmodulin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Cao, P]]
[[Category: Gong, Y]]
[[Category: Gui, W J]]
[[Category: Jiang, T]]
[[Category: Yu, H J]]
[[Category: Zhang, W T]]
[[Category: Calcium binding protein]]
[[Category: Calmodulin-peptide complex]]
[[Category: Death domain]]
[[Category: P75]]