View source for 3u90


==apoferritin: complex with SDS==
<StructureSection load='3u90' size='340' side='right' caption='[[3u90]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3u90]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U90 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SDS:DODECYL+SULFATE'>SDS</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f32|3f32]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u90 OCA], [http://pdbe.org/3u90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u90 RCSB], [http://www.ebi.ac.uk/pdbsum/3u90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u90 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Although sodium dodecyl sulfate (SDS) is widely used as an anionic detergent, it can also exert specific pharmacological effects that are independent of the surfactant properties of the molecule. However, structural details of how proteins recognize SDS are scarce. Here, it is demonstrated that SDS binds specifically to a naturally occurring four-helix bundle protein: horse apoferritin. The X-ray crystal structure of the apoferritin-SDS complex was determined at a resolution of 1.9 A and revealed that the SDS binds in an internal cavity that has previously been shown to recognize various general anesthetics. A dissociation constant of 24 +/- 9 microM at 293 K was determined by isothermal titration calorimetry. SDS binds in this cavity by bending its alkyl tail into a horseshoe shape; the charged SDS head group lies in the opening of the cavity at the protein surface. This crystal structure provides insights into the protein-SDS interactions that give rise to binding and may prove useful in the design of novel SDS-like ligands for some proteins.

Beyond the detergent effect: a binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin.,Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau JC, Dmochowski IJ, Loll PJ Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):497-504. Epub 2012 Apr 17. PMID:22525747<ref>PMID:22525747</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3u90" style="background-color:#fffaf0;"></div>

==See Also==
*[[Ferritin|Ferritin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Equus caballus]]
[[Category: Bu, W]]
[[Category: Cheung-Lau, J C]]
[[Category: Dmochowski, I J]]
[[Category: Liu, R]]
[[Category: Loll, P J]]
[[Category: Mortazavi, S R]]
[[Category: Xi, J]]
[[Category: Four helix bundle]]
[[Category: Intracellular protein]]
[[Category: Iron-binding protein]]
[[Category: Metal binding protein]]