View source for 4ez8


==Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate==
<StructureSection load='4ez8' size='340' side='right' caption='[[4ez8]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ez8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZ8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOH:2-DEOXY-N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NOH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ein|4ein]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tyms ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ez8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ez8 OCA], [http://pdbe.org/4ez8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ez8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ez8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ez8 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity). 

==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
__TOC__
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Thymidylate synthase]]
[[Category: Banaszak, K]]
[[Category: Dowiercial, A]]
[[Category: Gorecka, K]]
[[Category: Jarmula, A]]
[[Category: Kierdaszuk, B]]
[[Category: Rode, W]]
[[Category: Rypniewski, W]]
[[Category: Wilk, P]]
[[Category: Dihydrofolic acid]]
[[Category: Methyltransferase]]
[[Category: Ternary complex]]
[[Category: Transferase-transferase inhibitor complex]]