View source for 4iho


==Crystal structure of H-2Db Y159F in complex with chimeric gp100==
<StructureSection load='4iho' size='340' side='right' caption='[[4iho]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4iho]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IHO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ch1|3ch1]], [[3cch|3cch]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iho OCA], [http://pdbe.org/4iho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iho RCSB], [http://www.ebi.ac.uk/pdbsum/4iho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iho ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The immunogenicity of H-2Db (Db )-restricted epitopes can be significantly increased by substituting peptide position 3 to a proline (p3P). The p3P modification enhances MHC stability without altering the conformation of the modified epitope allowing for T-cell cross-reactivity with the native peptide. The present study reveals how specific interactions between p3P and the highly conserved MHC heavy chain residue Y159 increase the stability of Db in complex with an optimized version of the melanoma-associated epitope gp10025 -33 . Furthermore, the p3P modification directly increased the affinity of the Db /gp10025 -33 -specific T-cell receptor (TCR) pMel. Surprisingly, the enhanced TCR binding was independent from the observed increased stability of the optimized Db /gp10025 -33 complex and from the interactions formed between p3P and Y159, indicating a direct effect of the p3P modification on TCR recognition. This article is protected by copyright. All rights reserved.

Proline substitution independently enhances H-2D complex stabilization and TCR recognition of melanoma-associated peptides.,Uchtenhagen H, Abualrous ET, Stahl E, Allerbring EB, Sluijter M, Zacharias M, Sandalova T, van Hall T, Springer S, Nygren PA, Achour A Eur J Immunol. 2013 Aug 13. doi: 10.1002/eji.201343456. PMID:23939911<ref>PMID:23939911</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4iho" style="background-color:#fffaf0;"></div>

==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Achour, A]]
[[Category: Stahl, E]]
[[Category: Uchtenhagen, H]]
[[Category: Altered peptide ligand]]
[[Category: Disease mutation]]
[[Category: Glycoprotein]]
[[Category: H-2db]]
[[Category: Immune response]]
[[Category: Immune system]]
[[Category: Immunoglobulin domain]]
[[Category: Melanoma]]
[[Category: Mhc]]
[[Category: Mhc i]]
[[Category: T cell receptor]]
[[Category: Transmembrane]]
[[Category: Tumor associated antigen]]