View source for 3uqx


==Crystal structure of BACE1 with its inhibitor==
<StructureSection load='3uqx' size='340' side='right' caption='[[3uqx]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3uqx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UQX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene>, <scene name='pdbligand=ZPZ:N-[(1R)-1-(4-FLUOROPHENYL)ETHYL]-N-[(2S,3S)-3-HYDROXY-4-{4-[(1S)-1-HYDROXYETHYL]-1H-1,2,3-TRIAZOL-1-YL}-1-PHENYLBUTAN-2-YL]-5-[METHYL(METHYLSULFONYL)AMINO]BENZENE-1,3-DICARBOXAMIDE'>ZPZ</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uqp|3uqp]], [[4dv9|4dv9]], [[3uqr|3uqr]], [[4dvf|4dvf]], [[3uqu|3uqu]], [[3uqw|3uqw]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqx OCA], [http://pdbe.org/3uqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uqx RCSB], [http://www.ebi.ac.uk/pdbsum/3uqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uqx ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  

==See Also==
*[[Beta secretase|Beta secretase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Memapsin 2]]
[[Category: Chen, T T]]
[[Category: Chen, W Y]]
[[Category: Xu, Y C]]
[[Category: Bace1]]
[[Category: Beta-secretase]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]