View source for 4rdn


==Structure of YTH-YTHDF2 in complex with m6A==
<StructureSection load='4rdn' size='340' side='right' caption='[[4rdn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4rdn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RDN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MD:N-METHYLADENOSINE'>6MD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rdo|4rdo]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rdn OCA], [http://pdbe.org/4rdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rdn RCSB], [http://www.ebi.ac.uk/pdbsum/4rdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rdn ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN]] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Li, F D]]
[[Category: Shi, Y Y]]
[[Category: Wu, J H]]
[[Category: Zhao, D B]]
[[Category: Atypical beta-propeller]]
[[Category: M6a methylated rna]]
[[Category: M6a methylated rna binding]]
[[Category: Rna binding]]
[[Category: Rna binding protein]]