View source for 4gyu


==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 A121F mutant from Klebsiella pneumoniae==
<StructureSection load='4gyu' size='340' side='right' caption='[[4gyu]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gyu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GYU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gyu OCA], [http://pdbe.org/4gyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gyu RCSB], [http://www.ebi.ac.uk/pdbsum/4gyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gyu ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. 

==See Also==
*[[Beta-lactamase|Beta-lactamase]]
__TOC__
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Babnigg, J]]
[[Category: Binkowski, T A]]
[[Category: Jedrzejczak, R]]
[[Category: Joachimiak, A]]
[[Category: Kim, Y]]
[[Category: Structural genomic]]
[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
[[Category: Mire, J]]
[[Category: Sacchettini, J]]
[[Category: Tesar, C]]
[[Category: Alpha-beta-beta-alpha fold]]
[[Category: Hydrolase]]
[[Category: Mcsg]]
[[Category: Mtbi]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]