View source for 5clk


==Crystal structure of SZ348 in complex with S,S-cyclohexanediol==
<StructureSection load='5clk' size='340' side='right' caption='[[5clk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5clk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CLK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ZQ:(1S,2S)-CYCLOHEXANE-1,2-DIOL'>3ZQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cl6|5cl6]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Limonene-1,2-epoxide_hydrolase Limonene-1,2-epoxide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.8 3.3.2.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5clk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5clk OCA], [http://pdbe.org/5clk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5clk RCSB], [http://www.ebi.ac.uk/pdbsum/5clk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5clk ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LIMA_RHOER LIMA_RHOER]] Catalyzes the conversion of limonene-1,2-epoxide to limonene-1,2-diol. Can use both the (-) and (+) isomers of limonene-1,2-epoxide as substrates and also has some activity with 1-methylcyclohexene oxide, cyclohexene oxide and indene oxide as substrates. 
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</StructureSection>
[[Category: Limonene-1,2-epoxide hydrolase]]
[[Category: Reetz, M T]]
[[Category: Sun, Z T]]
[[Category: Wu, L]]
[[Category: Zhou, J H]]
[[Category: Epoxide hydrolase]]
[[Category: Hydrolase]]
[[Category: S-selective mutant]]