View source for 5ev6


==Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1==
<StructureSection load='5ev6' size='340' side='right' caption='[[5ev6]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [http://pdbe.org/5ev6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev6 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems. 
__TOC__
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Hinchliffe, P]]
[[Category: Spencer, J]]
[[Category: Antibiotic resistance]]
[[Category: Carbapenemase]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]