View source for 1is6

[[Image:1is6.jpg|left|200px]]

 {{Structure
|PDB= 1is6 |SIZE=350|CAPTION= <scene name='initialview01'>1is6</scene>, resolution 1.7&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=[[1c1l|1C1L]], [[1is3|1IS3]], [[1is4|1IS4]], [[1is5|1IS5]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1is6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1is6 OCA], [http://www.ebi.ac.uk/pdbsum/1is6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1is6 RCSB]</span>
}}

'''MES-Liganded Congerin II'''


==Overview==
The crystal structure of congerin II, a galectin family lectin from conger eel, was determined at 1.45A resolution. The previously determined structure of its isoform, congerin I, had revealed a fold evolution via strand swap; however, the structure of congerin II described here resembles other prototype galectins. A comparison of the two congerin genes with that of several other galectins suggests acceralated evolution of both congerin genes following gene duplication. The presence of a Mes (2-[N-morpholino]ethanesulfonic acid) molecule near the carbohydrate-binding site in the crystal structure points to the possibility of an additional binding site in congerin II. The binding site consists of a group of residues that had been replaced following gene duplication suggesting that the binding site was built under selective pressure. Congerin II may be a protein specialized for biological defense with an affinity for target carbohydrates on parasites' cell surface.

==About this Structure==
1IS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IS6 OCA]. 

==Reference==
Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication., Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12206768 12206768]
[[Category: Conger myriaster]]
[[Category: Single protein]]
[[Category: Ishii, C.]]
[[Category: Kamiya, H.]]
[[Category: Matsui, Y.]]
[[Category: Muramoto, K.]]
[[Category: Ogawa, T.]]
[[Category: Shionyu-Mitsuyama, C.]]
[[Category: Shirai, T.]]
[[Category: Yamane, T.]]
[[Category: beta sandwich]]
[[Category: mes complex]]

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