View source for 1hek

[[Image:1hek.gif|left|200px]]

 {{Structure
|PDB= 1hek |SIZE=350|CAPTION= <scene name='initialview01'>1hek</scene>, resolution 2.80&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
|ACTIVITY= 
|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11665 Equine infectious anemia virus])
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hek OCA], [http://www.ebi.ac.uk/pdbsum/1hek PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hek RCSB]</span>
}}

'''CRYSTAL STRUCTURE OF EQUINE INFECTIOUS ANAEMIA VIRUS MATRIX ANTIGEN (EIAV MA)'''


==Overview==
The Gag polyprotein is key to the budding of retroviruses from host cells and is cleaved upon virion maturation, the N-terminal membrane-binding domain forming the matrix protein (MA). The 2.8-A resolution crystal structure of MA of equine infectious anemia virus (EIAV), a lentivirus, reveals that, despite showing no sequence similarity, more than half of the molecule can be superimposed on the MAs of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV). However, unlike the structures formed by HIV-1 and SIV MAs, the oligomerization state observed is not trimeric. We discuss the potential of this molecule for membrane binding in the light of conformational differences between EIAV MA and HIV or SIV MA.

==About this Structure==
1HEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HEK OCA]. 

==Reference==
Structure of equine infectious anemia virus matrix protein., Hatanaka H, Iourin O, Rao Z, Fry E, Kingsman A, Stuart DI, J Virol. 2002 Feb;76(4):1876-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11799182 11799182]
[[Category: Equine infectious anemia virus]]
[[Category: Single protein]]
[[Category: Fry, E.]]
[[Category: Hatanaka, H.]]
[[Category: Iourin, O.]]
[[Category: Kingsman, A.]]
[[Category: Rao, Z.]]
[[Category: Stuart, D I.]]
[[Category: membrane-binding switching]]
[[Category: viral protein]]

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