View source for 1fv9

[[Image:1fv9.gif|left|200px]]

 {{Structure
|PDB= 1fv9 |SIZE=350|CAPTION= <scene name='initialview01'>1fv9</scene>, resolution 3.00&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=172:2-AMINO-5-HYDROXY-BENZIMIDAZOLE'>172</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span>
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv9 OCA], [http://www.ebi.ac.uk/pdbsum/1fv9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fv9 RCSB]</span>
}}

'''Crystal structure of human microurokinase in complex with 2-amino-5-hydroxy-benzimidazole'''


==Overview==
Using an NMR-based screen, a novel class of urokinase inhibitors were identified that contain a 2-aminobenzimidazole moiety. The inhibitory potency of this family of inhibitors is similar to that of inhibitors containing a guanidine or amidine group. However, unlike previously described guanidino- or amidino-based inhibitors which have pK(a) values greater than 9.0, urokinase inhibitors containing a 2-aminobenzimidazole have pK(a) values of 7.5. Thus, 2-aminobenzimidazoles may have improved pharmacokinetic properties which could increase the bioavailability of inhibitors which contain this moiety. A crystal structure of one of the lead inhibitors, 2-amino-5-hydroxybenzimidazole, complexed with urokinase reveals the electrostatic and hydrophobic interactions that stabilize complex formation and suggests nearby subsites that may be accessed to increase the potency of this new series of urokinase inhibitors.

==About this Structure==
1FV9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV9 OCA]. 

==Reference==
Identification of novel inhibitors of urokinase via NMR-based screening., Hajduk PJ, Boyd S, Nettesheim D, Nienaber V, Severin J, Smith R, Davidson D, Rockway T, Fesik SW, J Med Chem. 2000 Oct 19;43(21):3862-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11052791 11052791]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: U-plasminogen activator]]
[[Category: Nienaber, V.]]
[[Category: plasminogen activation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:30:57 2008''