View source for 2e5i

==Solution structure of RNA binding domain 2 in Heterogeneous nuclear ribonucleoprotein L-like==
<StructureSection load='2e5i' size='340' side='right' caption='[[2e5i]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2e5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5I FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hnrpll ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5i OCA], [http://pdbe.org/2e5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5i RCSB], [http://www.ebi.ac.uk/pdbsum/2e5i PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5i TOPSAN]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HNRLL_MOUSE HNRLL_MOUSE]] RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5i_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5i ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Nucleoprotein|Nucleoprotein]]
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</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Inoue, M]]
[[Category: Kigawa, T]]
[[Category: Muto, Y]]
[[Category: Structural genomic]]
[[Category: Shirouzu, M]]
[[Category: Terada, T]]
[[Category: Tsuda, K]]
[[Category: Yokoyama, S]]
[[Category: Gene regulation]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rbd]]
[[Category: Rrm domain]]
[[Category: Rsgi]]