View source for 2ysv

==Solution structure of C2H2 type Zinc finger domain 17 in Zinc finger protein 473==
<StructureSection load='2ysv' size='340' side='right' caption='[[2ysv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ysv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YSV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF473, KIAA1141, ZFP100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ysv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ysv OCA], [http://pdbe.org/2ysv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ysv RCSB], [http://www.ebi.ac.uk/pdbsum/2ysv PDBsum], [http://www.topsan.org/Proteins/RSGI/2ysv TOPSAN]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN]] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/2ysv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ysv ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Zinc Fingers|Zinc Fingers]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Inoue, M]]
[[Category: Kigawa, T]]
[[Category: Muto, Y]]
[[Category: Structural genomic]]
[[Category: Shirouzu, M]]
[[Category: Terada, T]]
[[Category: Tsuda, K]]
[[Category: Yokoyama, S]]
[[Category: C2h2]]
[[Category: Metal binding protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Zinc finger domain]]