View source for 1epp

[[Image:1epp.gif|left|200px]]

 {{Structure
|PDB= 1epp |SIZE=350|CAPTION= <scene name='initialview01'>1epp</scene>, resolution 1.9&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=DCI:2-METHYL-BUTYLAMINE'>DCI</scene>, <scene name='pdbligand=MAS:DIMETHYLSULFONIC+AMIDE'>MAS</scene>, <scene name='pdbligand=MTF:N-METHYLTHIOFORMAMIDE'>MTF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span>
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epp OCA], [http://www.ebi.ac.uk/pdbsum/1epp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1epp RCSB]</span>
}}

'''ANALYSES OF LIGAND BINDING IN FIVE ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS'''


==Overview==
Five renin inhibitors were cocrystallized with endothiapepsin, a fungal enzyme homologous to renin. Crystal structures of inhibitor-bound complexes have provided invaluable insight regarding the three-dimensional structure of the aspartic proteinase family of enzymes, as well as the steric and polar interactions that occur between the proteins and the bound ligands. Beyond this, subtleties of binding have been revealed, including multiple subsite binding modes and subsite interdependencies. This information has been applied in the design of novel potent renin inhibitors and in the understanding of structure-activity relationships and enzyme selectivities.

==About this Structure==
1EPP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPP OCA]. 

==Reference==
Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors., Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al., J Med Chem. 1993 Nov 26;36(24):3809-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8254610 8254610]
[[Category: Endothiapepsin]]
[[Category: Single protein]]
[[Category: Blundell, T L.]]
[[Category: Cooper, J B.]]
[[Category: Wallace, B A.]]
[[Category: hydrolase(acid proteinase)]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:07:20 2008''