View source for 1db1

[[Image:1db1.gif|left|200px]]

 {{Structure
|PDB= 1db1 |SIZE=350|CAPTION= <scene name='initialview01'>1db1</scene>, resolution 1.8&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=VDX:5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL'>VDX</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1db1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1db1 OCA], [http://www.ebi.ac.uk/pdbsum/1db1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1db1 RCSB]</span>
}}

'''CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D'''


==Overview==
The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear receptor (VDR), a ligand-dependent transcription regulator. We report the 1.8 A resolution crystal structure of the complex between a VDR ligand-binding domain (LBD) construct lacking the highly variable VDR-specific insertion domain and vitamin D. The construct exhibits the same binding affinity for vitamin D and transactivation ability as the wild-type protein, showing that the N-terminal part of the LBD is essential for its structural and functional integrity while the large insertion peptide is dispensable. The structure reveals the active conformation of the bound ligand and allows understanding of the different binding properties of some synthetic analogs.

==About this Structure==
1DB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DB1 OCA]. 

==Reference==
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand., Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D, Mol Cell. 2000 Jan;5(1):173-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10678179 10678179]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Klaholz, B.]]
[[Category: Mitschler, A.]]
[[Category: Moras, D.]]
[[Category: Rochel, N.]]
[[Category: Wurtz, J M.]]
[[Category: complex]]

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