View source for 1cx0

[[Image:1cx0.gif|left|200px]]

 {{Structure
|PDB= 1cx0 |SIZE=350|CAPTION= <scene name='initialview01'>1cx0</scene>, resolution 2.30&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=[[1drz|1DRZ]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cx0 OCA], [http://www.ebi.ac.uk/pdbsum/1cx0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cx0 RCSB]</span>
}}

'''HEPATITIS DELTA VIRUS RIBOZYME'''


==Overview==
The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.

==About this Structure==
1CX0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX0 OCA]. 

==Reference==
Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9783582 9783582]
[[Category: Hepatitis delta virus]]
[[Category: Single protein]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Doudna, J A.]]
[[Category: Zhou, K.]]
[[Category: nested double pseudoknot rna structure]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:30:17 2008''