View source for 1cok

[[Image:1cok.gif|left|200px]]

 {{Structure
|PDB= 1cok |SIZE=350|CAPTION= <scene name='initialview01'>1cok</scene>
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cok OCA], [http://www.ebi.ac.uk/pdbsum/1cok PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cok RCSB]</span>
}}

'''STRUCTURE OF THE C-TERMINAL DOMAIN OF P73'''


==Overview==
p73 and p63 are two recently cloned genes with homology to the tumor suppressor p53, whose protein product is a key transcriptional regulator of genes involved in cell cycle arrest and apoptosis. While all three proteins share conserved transcriptional activation, DNA-binding and oligomerization domains, p73 and p63 have an additional conserved C-terminal region. We have determined the three-dimensional solution structure of this conserved C-terminal domain of human p73. The structure reveals a small five-helix bundle with striking similarity to the SAM (sterile alpha motif) domains of two ephrin receptor tyrosine kinases. The SAM domain is a putative protein-protein interaction domain found in a variety of cytoplasmic signaling proteins and has been shown to form both homo- and hetero-oligomers. However, the SAM-like C-terminal domains of p73 and p63 are monomeric and do not interact with one another, suggesting that this domain may interact with additional, as yet uncharacterized proteins in a signaling and/or regulatory role.

==About this Structure==
1COK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COK OCA]. 

==Reference==
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10449409 10449409]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Arrowsmith, C H.]]
[[Category: Ayed, A.]]
[[Category: Chi, S W.]]
[[Category: gene regulation]]
[[Category: p73 sam-like domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:25:30 2008''