View source for 2dar

==Solution structure of first LIM domain of Enigma-like PDZ and LIM domains protein==
<StructureSection load='2dar' size='340' side='right' caption='[[2dar]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dar]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DAR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dar OCA], [http://pdbe.org/2dar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dar RCSB], [http://www.ebi.ac.uk/pdbsum/2dar PDBsum], [http://www.topsan.org/Proteins/RSGI/2dar TOPSAN]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PDLI5_HUMAN PDLI5_HUMAN]] May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2dar_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dar ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Group:MUZIC:Enigma Family|MUZIC:Enigma Family]]
*[[PDZ and LIM domain protein|PDZ and LIM domain protein]]
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Inoue, M]]
[[Category: Kigawa, T]]
[[Category: Koshiba, S]]
[[Category: Muto, Y]]
[[Category: Niraula, T N]]
[[Category: Structural genomic]]
[[Category: Yokoyama, S]]
[[Category: Enigma homolog protein]]
[[Category: Lim domain]]
[[Category: Metal binding protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]