View source for 5dsv

==Crystal structure of human proteasome alpha7 tetradecamer==
<StructureSection load='5dsv' size='340' side='right' caption='[[5dsv]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dsv]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DSV FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsv OCA], [http://pdbe.org/5dsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dsv RCSB], [http://www.ebi.ac.uk/pdbsum/5dsv PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PSA3_HUMAN PSA3_HUMAN]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.<ref>PMID:11350925</ref> <ref>PMID:17499743</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Proteasome endopeptidase complex]]
[[Category: Kato, K]]
[[Category: Satoh, T]]
[[Category: Seetaha, S]]
[[Category: Thammaporn, R]]
[[Category: Hydrolase]]
[[Category: Proteasome]]