View source for 1aei

[[Image:1aei.jpg|left|200px]]

 {{Structure
|PDB= 1aei |SIZE=350|CAPTION= <scene name='initialview01'>1aei</scene>, resolution 2.8&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
|ACTIVITY= 
|GENE= 
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aei OCA], [http://www.ebi.ac.uk/pdbsum/1aei PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aei RCSB]</span>
}}

'''CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER'''


==Overview==
Annexins are a family of calcium- and phospholipid-binding proteins implicated in a number of biological processes including membrane fusion and ion channel formation. The crystal structure of the annexin XII hexamer, refined at 2.8 A resolution, forms a concave disk with 3-2 symmetry, about 100 A in diameter and 70 A thick with a central hydrophilic pore. Six intermolecular Ca2+ ions are involved in hexamer formation. An additional 18 Ca2+ ions are located on the perimeter of the disk, accessible only from the side of the hexameric disk. On the basis of the hexamer structure we propose here a new mode of protein-phospholipid bilayer interaction that is distinct from the hydrophobic insertion of typical membrane proteins. This speculative model postulates the Ca(2+)-dependent insertion of the hydrophilic annexin XII hexamer into phospholipid bilayers with local reorientation of the bilayer phospholipids.

==About this Structure==
1AEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEI OCA]. 

==Reference==
Crystal structure of the annexin XII hexamer and implications for bilayer insertion., Luecke H, Chang BT, Mailliard WS, Schlaepfer DD, Haigler HT, Nature. 1995 Nov 30;378(6556):512-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7477411 7477411]
[[Category: Hydra vulgaris]]
[[Category: Single protein]]
[[Category: Chang, B T.]]
[[Category: Haigler, H T.]]
[[Category: Luecke, H.]]
[[Category: Mailliard, W S.]]
[[Category: Schlaepfer, D D.]]
[[Category: annexin]]
[[Category: calcium]]
[[Category: calcium/phospholipid-binding]]
[[Category: phospholipid]]

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