View source for 1uw3

[[Image:1uw3.gif|left|200px]]<br />
<applet load="1uw3" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1uw3, resolution 2.05&Aring;" />
'''THE CRYSTAL STRUCTURE OF THE GLOBULAR DOMAIN OF SHEEP PRION PROTEIN'''<br />

==Overview==
The prion protein PrP is a naturally occurring polypeptide that becomes, transformed from a normal conformation to that of an aggregated form, characteristic of pathological states in fatal transmissible spongiform, conditions such as Creutzfeld-Jacob Disease and Bovine Spongiform, Encephalopathy. We report the crystal structure, at 2 A resolution, of, residues 123-230 of the C-terminal globular domain of the ARQ allele of, sheep prion protein (PrP). The asymmetric unit contains a single molecule, whose secondary structure and overall organisation correspond to those, structures of PrPs from various mammalian species determined by NMR. The, globular domain shows a close association of helix-1, the C-terminal, portion of helix-2 and the N-terminal portion of helix-3, bounded by the, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15037077 (full description)]]

==About this Structure==
1UW3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]] with PO4 and GTT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UW3 OCA]]. 

==Reference==
The crystal structure of the globular domain of sheep prion protein., Haire LF, Whyte SM, Vasisht N, Gill AC, Verma C, Dodson EJ, Dodson GG, Bayley PM, J Mol Biol. 2004 Mar 5;336(5):1175-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15037077 15037077]
[[Category: Ovis aries]]
[[Category: Single protein]]
[[Category: Bayley, P.M.]]
[[Category: Dodson, E.J.]]
[[Category: Dodson, G.G.]]
[[Category: Gill, A.C.]]
[[Category: Haire, L.F.]]
[[Category: Vasisht, N.]]
[[Category: Verma, C.]]
[[Category: Whyte, S.M.]]
[[Category: GTT]]
[[Category: PO4]]
[[Category: creutzfeld jacob disease]]
[[Category: prion protein]]
[[Category: sheep]]
[[Category: transmissible spongiform encephalopathy]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:10:00 2007''