View source for 4uci

==X-ray structure and activities of an essential Mononegavirales L- protein domain==
<StructureSection load='4uci' size='340' side='right' caption='[[4uci]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uci]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UCI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ucj|4ucj]], [[4uck|4uck]], [[4ucl|4ucl]], [[4ucy|4ucy]], [[4ucz|4ucz]], [[4ud0|4ud0]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uci OCA], [http://pdbe.org/4uci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uci RCSB], [http://www.ebi.ac.uk/pdbsum/4uci PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/L_HMPVC L_HMPVC]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity). 
__TOC__
</StructureSection>
[[Category: Canard, B]]
[[Category: Collet, A]]
[[Category: Debart, F]]
[[Category: Decroly, E]]
[[Category: Grimes, J M]]
[[Category: Paesen, G C]]
[[Category: Sallamand, C]]
[[Category: Vasseur, J J]]
[[Category: Adenosine]]
[[Category: Capping]]
[[Category: Gtp]]
[[Category: L protein]]
[[Category: Methyltransferase]]
[[Category: Rossmann]]
[[Category: S-adenosyl methionine]]
[[Category: Transferase]]
[[Category: Triphosphatase]]