View source for 1rh7

[[Image:1rh7.gif|left|200px]]

 {{Structure
|PDB= 1rh7 |SIZE=350|CAPTION= <scene name='initialview01'>1rh7</scene>, resolution 3.106&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>
|ACTIVITY= 
|GENE= RETNLB or FIZZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06954 Resistin]</span>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rh7 OCA], [http://www.ebi.ac.uk/pdbsum/1rh7 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1rh7 RCSB]</span>
}}

'''Crystal Structure of Resistin-like beta'''


==Overview==
Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.

==About this Structure==
1RH7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RH7 OCA]. 

==Reference==
Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15155948 15155948]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Burley, S K.]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Patel, S D.]]
[[Category: Rajala, M W.]]
[[Category: Scherer, P E.]]
[[Category: Shapiro, L.]]
[[Category: glucose uptake]]
[[Category: hormone]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: resistin/fizz family]]
[[Category: structural genomic]]

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