View source for 2jcr

==THE HYALURONAN BINDING DOMAIN OF MURINE CD44 IN A TYPE B COMPLEX WITH AN HA 8-MER==
<StructureSection load='2jcr' size='340' side='right' caption='[[2jcr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2jcr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jcp|2jcp]], [[2jcq|2jcq]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcr OCA], [http://pdbe.org/2jcr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jcr RCSB], [http://www.ebi.ac.uk/pdbsum/2jcr PDBsum]</span></td></tr>
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== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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== Publication Abstract from PubMed ==
Regulation of transient interactions between cells and the ubiquitous matrix glycosaminoglycan hyaluronan is crucial to such fundamental processes as embryonic development and leukocyte homing. Cd44, the primary cell surface receptor for hyaluronan, binds ligand via a lectin-like fold termed the Link module, but only after appropriate functional activation. The molecular details of the Cd44-hyaluronan interaction and hence the structural basis for this activation are unknown. Here we present the first crystal structure of Cd44 complexed with hyaluronan. This reveals that the interaction with hyaluronan is dominated by shape and hydrogen-bonding complementarity and identifies two conformational forms of the receptor that differ in orientation of a crucial hyaluronan-binding residue (Arg45, equivalent to Arg41 in human CD44). Measurements by NMR indicate that the conformational transition can be induced by hyaluronan binding, providing further insight into possible mechanisms for regulation of Cd44.

Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction.,Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874<ref>PMID:17293874</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2jcr" style="background-color:#fffaf0;"></div>

==See Also==
*[[CD44|CD44]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Banerji, S]]
[[Category: Campbell, I D]]
[[Category: Day, A J]]
[[Category: Jackson, D G]]
[[Category: Mahoney, D J]]
[[Category: Noble, M E.M]]
[[Category: Wright, A J]]
[[Category: Antigen]]
[[Category: Blood group antigen]]
[[Category: C-type lectin]]
[[Category: Cell adhesion]]
[[Category: Extracellular matrix]]
[[Category: Glycoprotein]]
[[Category: Hyauronan]]
[[Category: Lectin]]
[[Category: Link-domain]]
[[Category: Membrane]]
[[Category: Phosphorylation]]
[[Category: Proteoglycan]]
[[Category: Pyrrolidone carboxylic acid]]
[[Category: Receptor]]
[[Category: Sugar-binding]]
[[Category: Sugar-binding protein]]
[[Category: Sulfation]]
[[Category: Transmembrane]]