View source for 1ot0

==Structure of Antimicrobial Peptide, HP (2-20) and its Analogues Derived from Helicobacter pylori, as Determined by 1H NMR Spectroscopy==
<StructureSection load='1ot0' size='340' side='right' caption='[[1ot0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ot0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OT0 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ot0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ot0 OCA], [http://pdbe.org/1ot0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ot0 RCSB], [http://www.ebi.ac.uk/pdbsum/1ot0 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RL1_HELPY RL1_HELPY]] Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity).[HAMAP-Rule:MF_01318]  Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318]  Peptides originating from the N-terminal end of L1 have antibacterial activity against bacteria such as E.coli and B.megaterium and modest antifungal activities. Has no effect on H.pylori itself. Peptides are not hemolytic against mammalian cells. These peptides may be released in the stomach during altruistic lysis to kill other fast growing bacteria.[HAMAP-Rule:MF_01318] 
__TOC__
</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Hahm, K S]]
[[Category: Kim, Y]]
[[Category: Lee, D G]]
[[Category: Lee, K H]]
[[Category: Park, Y]]
[[Category: Antibiotic]]
[[Category: Coil-helix-coil]]
[[Category: Ribosomal protein]]
[[Category: Rrna-binding]]