View source for 2i3y

==Crystal structure of human glutathione peroxidase 5==
<StructureSection load='2i3y' size='340' side='right' caption='[[2i3y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2i3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I3Y FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i3y OCA], [http://pdbe.org/2i3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i3y RCSB], [http://www.ebi.ac.uk/pdbsum/2i3y PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GPX5_HUMAN GPX5_HUMAN]] Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/2i3y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Glutathione peroxidase|Glutathione peroxidase]]
__TOC__
</StructureSection>
[[Category: Glutathione peroxidase]]
[[Category: Human]]
[[Category: Arrowsmith, C]]
[[Category: Bunkoczi, G]]
[[Category: Delft, F Von]]
[[Category: Edwards, A]]
[[Category: Gileadi, O]]
[[Category: Johansson, C]]
[[Category: Kavanagh, K L]]
[[Category: Oppermann, U]]
[[Category: Rojkova, A]]
[[Category: Structural genomic]]
[[Category: Sundstrom, M]]
[[Category: Umeano, C]]
[[Category: Weigelt, J]]
[[Category: Epididymal androgen related protein]]
[[Category: Oxidoreductase]]
[[Category: Sgc]]
[[Category: Thioredoxin fold]]