View source for 1tkf

==Streptomyces griseus aminopeptidase complexed with D-tryptophan==
<StructureSection load='1tkf' size='340' side='right' caption='[[1tkf]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_griseus"_krainsky_1914 "actinomyces griseus" krainsky 1914]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TKF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xjo|1xjo]], [[1cp7|1cp7]], [[1qq9|1qq9]], [[1f2p|1f2p]], [[1f2o|1f2o]], [[1tf8|1tf8]], [[1tf9|1tf9]], [[1tkh|1tkh]], [[1tkj|1tkj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tkf OCA], [http://pdbe.org/1tkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tkf RCSB], [http://www.ebi.ac.uk/pdbsum/1tkf PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/APX_STRGR APX_STRGR]] Specific for larger hydrophobic acids, especially leucine. No cleavage occurs if the next residue is proline. 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tk/1tkf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Aminopeptidase|Aminopeptidase]]
*[[Streptomyces griseus Aminopeptidase (SGAP)|Streptomyces griseus Aminopeptidase (SGAP)]]
__TOC__
</StructureSection>
[[Category: Actinomyces griseus krainsky 1914]]
[[Category: Blumberg, S]]
[[Category: Gilboa, R]]
[[Category: Reiland, V]]
[[Category: Schomburg, D]]
[[Category: Shoham, G]]
[[Category: Shoham, Y]]
[[Category: Spungin-Bialik, A]]
[[Category: Calcium activation]]
[[Category: Double-zinc metalloproteinase]]
[[Category: Hydrolase]]
[[Category: Protein-inhibitor complex]]