View source for 1yxq

[[Image:1yxq.gif|left|200px]]

 {{Structure
|PDB= 1yxq |SIZE=350|CAPTION= <scene name='initialview01'>1yxq</scene>, resolution 2.01&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=SWI:SWINHOLIDE+A'>SWI</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
|ACTIVITY= 
|GENE= 
}}

'''Crystal structure of actin in complex with swinholide A'''


==Overview==
Marine toxins targeting the actin cytoskeleton represent a new and promising class of anti-cancer compounds. Here we present a 2.0 A resolution structure of swinholide A, a marine macrolide, bound to two actin molecules. The structure demonstrates that the actin dimer in the complex does not represent a physiologically relevant entity, for the two actin molecules do not interact with each other. The swinholide A actin binding site is the same as that targeted by toxins of the trisoxazole family and numerous actin binding proteins, highlighting the importance of this site in actin polymerization. The observed structure reveals the mechanism of action of swinholide A and provides a structural framework about which to design new agents directed at the cytoskeleton.

==About this Structure==
1YXQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXQ OCA]. 

==Reference==
Structural basis of swinholide A binding to actin., Klenchin VA, King R, Tanaka J, Marriott G, Rayment I, Chem Biol. 2005 Mar;12(3):287-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15797212 15797212]
[[Category: Oryctolagus cuniculus]]
[[Category: Single protein]]
[[Category: King, R.]]
[[Category: Klenchin, V A.]]
[[Category: Marriott, G.]]
[[Category: Rayment, I.]]
[[Category: Tanaka, J.]]
[[Category: ATP]]
[[Category: EDO]]
[[Category: MG]]
[[Category: SWI]]
[[Category: actin; swinholide a; macrolide toxin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:24:44 2008''