View source for 1hmh

==THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME==
<StructureSection load='1hmh' size='340' side='right' caption='[[1hmh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1hmh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HMH FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmh OCA], [http://pdbe.org/1hmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hmh RCSB], [http://www.ebi.ac.uk/pdbsum/1hmh PDBsum]</span></td></tr>
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== Publication Abstract from PubMed ==
The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired stems and a core of highly conserved, non-complementary nucleotides essential for catalysis. The X-ray crystallographic structure of a hammerhead RNA-DNA ribozyme-inhibitor complex at 2.6 A resolution reveals that the base-paired stems are A-form helices and that the core has two structural domains. The first domain is formed by the sequence 5'-CUGA following stem I and is a sharp turn identical to the uridine turn of transfer RNA, whereas the second is a non-Watson-Crick three-base-pair duplex with a divalent-ion binding site. The phosphodiester backbone of the DNA inhibitor strand is splayed out at the phosphate 5' to the cleavage site. The structure indicates that the ribozyme may destabilize a substrate strand in order to facilitate twisting of the substrate to allow cleavage of the scissile bond.

Three-dimensional structure of a hammerhead ribozyme.,Pley HW, Flaherty KM, McKay DB Nature. 1994 Nov 3;372(6501):68-74. PMID:7969422<ref>PMID:7969422</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
*[[Ribozyme|Ribozyme]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Flaherty, K M]]
[[Category: McKay, D B]]
[[Category: Pley, H W]]
[[Category: Dna-rna hammerhead ribozyme]]
[[Category: Loop]]
[[Category: Ribozyme]]