View source for 2npt

==Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)==
<StructureSection load='2npt' size='340' side='right' caption='[[2npt]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2npt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NPT FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP2K5, MEK5, MKK5, PRKMK5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MAP3K2, MAPKKK2, MEKK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npt OCA], [http://pdbe.org/2npt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2npt RCSB], [http://www.ebi.ac.uk/pdbsum/2npt PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN]] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref>  [[http://www.uniprot.org/uniprot/M3K2_HUMAN M3K2_HUMAN]] Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.<ref>PMID:10713157</ref> <ref>PMID:16001074</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/2npt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Mitogen-activated protein kinase kinase]]
[[Category: Arrowsmith, C]]
[[Category: Debreczeni, J]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Filippakopoulos, P]]
[[Category: Knapp, S]]
[[Category: Papagrigoriou, V]]
[[Category: Structural genomic]]
[[Category: Sundstrom, M]]
[[Category: Turnbull, A]]
[[Category: Map kinase kinase 5]]
[[Category: Map2k5]]
[[Category: Map3k2]]
[[Category: Mapk/erk kinase kinase 2]]
[[Category: Mapkkk2]]
[[Category: Mek kinase 2]]
[[Category: Mek5]]
[[Category: Mekk2]]
[[Category: Mekk2b]]
[[Category: Mitogen activated protein kinase kinase 5]]
[[Category: Mitogen activated protein kinase kinase kinase 2]]
[[Category: Mkk5]]
[[Category: Phox]]
[[Category: Phox-domain]]
[[Category: Prkmk5]]
[[Category: Sgc]]
[[Category: Transferase]]