View source for 1gtt

[[Image:1gtt.gif|left|200px]]<br />
<applet load="1gtt" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1gtt, resolution 1.70&Aring;" />
'''CRYSTAL STRUCTURE OF HPCE'''<br />

==Overview==
The structure of the bifunctional enzyme HpcE (OPET decarboxylase/HHDD, isomerase) from Escherichia coli shows that the protein consists of highly, similar N and C terminal halves. Sequence matches suggest that this fold, is widespread among different species, including man. Many of these, homologues are uncharacterized but apparently connected with the, metabolism of aromatic compounds. The domain shows similar topology to the, C terminal domain of fumarylacetoacetate hydrolase (FAH), a functionally, related enzyme, despite lacking significant overall sequence similarity., HpcE is known to catalyze two rather different reactions, and comparisons, with FAH allow some tentative conclusions to be drawn about the active, sites. Key mutations within the active site apparently allow enzymes with, this fold to carry out a variety chemical processes.

==About this Structure==
1GTT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: CA1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GTT OCA]. 

==Reference==
The crystal structure of HpcE, a bifunctional decarboxylase/isomerase with a multifunctional fold., Tame JR, Namba K, Dodson EJ, Roper DI, Biochemistry. 2002 Mar 5;41(9):2982-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11863436 11863436]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Dodson, E.J.]]
[[Category: Namba, K.]]
[[Category: Roper, D.I.]]
[[Category: Tame, J.R.H.]]
[[Category: CA]]
[[Category: aromatic hydrocarbons catabolism]]
[[Category: bifunctional enzyme]]
[[Category: isomerase]]
[[Category: lyase]]
[[Category: multifunctional enzyme decarboxylase]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 14:37:02 2007''