View source for 4uu9

==Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody==
<StructureSection load='4uu9' size='340' side='right' caption='[[4uu9]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4uu9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UU9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uu9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uu9 RCSB], [http://www.ebi.ac.uk/pdbsum/4uu9 PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[http://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.  Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). 
== Function ==
[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.  Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). 
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</StructureSection>
[[Category: Bonnell, J]]
[[Category: Brennan, J]]
[[Category: Colley, C]]
[[Category: Davies, R]]
[[Category: Debreczeni, J E]]
[[Category: Dobson, C]]
[[Category: Edwards, B]]
[[Category: Eghobamien, L An]]
[[Category: England, L]]
[[Category: Flavell, L]]
[[Category: Fung, S]]
[[Category: Hargreaves, D]]
[[Category: Howes, R]]
[[Category: Popovic, B]]
[[Category: Renshaw, G J]]
[[Category: Sivars, U]]
[[Category: Sridharan, S]]
[[Category: Vaughan, T]]
[[Category: Warrener, P]]
[[Category: Wickson, K]]
[[Category: Wilkinson, T]]
[[Category: Woods, R]]
[[Category: Complement system]]
[[Category: Fv]]
[[Category: Immune system]]